Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Wednesday, 01 / 29 / 2020

Articles

Baseline Characteristics and Treatment Patterns of the Patients Recruited to the China Registry of Hepatitis B

ORIGINAL ARTICLE

Baseline Characteristics and Treatment Patterns of the Patients Recruited to the China Registry of Hepatitis B

Shan Shan1, Hong You1, Junqi Niu2, Jia Shang3, Wen Xie4, Yuexin Zhang5, Xun Li6, Hong Ren7, Hong Tang8, Huiguo Ding9, Xihong Wang10, Yuemin Nan11, Xiaoguang Dou12, Tao Han13, Lingyi Zhang14, Xiaoqing Liu15, Cunliang Deng16, Jilin Cheng17, Xiaozhong Wang18, Qing Xie19, Shumei Lin20, Yan Huang21, Youqing Xu22, Yong Xiong23, Wu Li24, Xuebing Yan25, Hongxin Piao26, Wenxiang Huang27, Qinghua Lu28, Weijin Gong29, Shiping Li30, Xiaoxuan Hu31, Xiaolan Zhang32, Shourong Liu33, Yufang Li34, Dongliang Yang35, Hai Li36, Caixia Yang37, Mingliang Cheng38, Liaoyun Zhang39, Huanwei Zheng40, Xinhua Luo41, Feng Lin42, Lei Wang43, Guanghua Xu44, Xiaoyuan Xu45, Lai Wei46, Jinlin Hou47, Zhongping Duan48, Hui Zhuang49, Xizhong Yang50, Yuanyuan Kong51,*, Jidong Jia1,* and for the CR-HepB study group, Beijing, China

1Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China
2Department of Hepatology, First Hospital of Jilin University, Changchun, Jilin, China
3Department of Infectious Diseases, Henan Provincial People’s Hospital, Zhengzhou, Henan, China
4Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
5Department of Infectious Diseases, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China
6Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
7Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
8Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan, China
9Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China
10Center of Infectious Diseases, The Third People’s Hospital of Taiyuan, Taiyuan, Shanxi, China
11Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
12Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
13Department of Hepatology, Tianjin Third Central Hospital, Tianjin Medical University, Tianjin, China
14Department of Hepatology, Lanzhou University Second Hospital, Lanzhou, Gansu, China
15Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing, China
16Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, Gansu, China
17Department of Gastroenterology, Shanghai Public Health Clinical Center, Shanghai, China
18Department of Hepatology, Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital, Urumqi, Xinjiang, China
19Department of Infectious Diseases, Shanghai Ruijin Hospital, Jiao Tong University School of Medicine, Shanghai, China
20Department of Infectious Diseases, The First Affiliated Hospital of Xian Jiao Tong University, Xi’an, Shaanxi, China
21Department of Infectious Diseases, Xiangya Hospital Central South University, Changsha, Hunan, China
22Department of Digestive System, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
23Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
24Department of Infectious Diseases, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
25Department of Infectious Diseases, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Henan, China
26Department of Infectious Diseases, Yanbian University Hospital, Yanji, Jilin, China
27Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
28Department of Hepatology, The Fourth People’s Hospital of Qinghai Province, Xining, Qinghai, China
29Department of Infectious Diseases, Xinjiang Changji Prefecture People’s Hospital, Changji, Xinjiang, China
30Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China
31Department of Hepatology, Hunan Provincial People’s Hospital, Changsha, Hunan, China
32Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
33Department of Hepatology, Xixi Hospital of Hangzhou, Hangzhou, Zhejiang, China
34Department of Infectious Diseases, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
35Department of Infectious Diseases, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China
36Department of Hepatopancreatobiliary and Splenic Medicine, The Affiliated Hospital, Logistics University of People’s Armed Police Force, Tianjin, China
37Department of Infectious Diseases, Infectious Disease Hospital of Wuhai, Wuhai, Inner Mongolia, China
38Department of Infectious Diseases, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
39Department of Infectious Diseases, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
40Department of Infectious Diseases, The Fifth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
41Department of Infectious Diseases, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
42Department of Infectious Diseases, Hainan General Hospital, Haikou, Hainan, China
43Department of Infectious Diseases, The Second Hospital of Shandong University, Jinan, Shandong, China
44Department of Infectious Diseases, Yanan University Affiliated Hospital, Yan’an, Shaanxi, China
45Department of Infectious Diseases, Peking University First Hospital, Beijing, China
46Peking University Hepatology Institute, Peking University People’s Hospital, Beijing, China
47Institute of Hepatology and Department of Infectious Disease, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
48Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China
49Department of Microbiology and Infectious Disease Center, Peking University Health Science Center, Beijing, China
50The China Foundation of Hepatitis Prevention and Control, Beijing China
51Center for Clinical Epidemiology and EBM, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China

*Correspondence to: Jidong Jia, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Xicheng District, Beijing 100050, China. Tel & Fax: +86-10-63139246, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; Yuanyuan Kong, Center for Clinical Epidemiology and EBM, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Xicheng District, Beijing 100050, China. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(4):322-328 DOI: 10.14218/JCTH.2019.00052
Received: October 13, 2019 Accepted: December 11, 2019 Published online: December 20, 2019

Abstract

Background and Aims: Chronic hepatitis B virus (HBV) infection remains a major public health problem globally. Here, we describe the baseline characteristics and treatment profiles of HBV-infected patients recruited to the China Registry of Hepatitis B.

Methods: Inclusion criteria were patients with different stages of chronic HBV infection and complete key data. Exclusion criteria were patients with hepatocellular carcinoma. The baseline clinical, laboratory and treatment profiles were analyzed.

Results: Finally, 40,431 patients were included. The median age was 43 years, with 65.2% being men and 51.3% being positive for hepatitis B e antigen (HBeAg). The most common initial diagnosis was chronic hepatitis B (81.0%), followed by cirrhosis (9.3%), inactive carrier of hepatitis B surface antigen (HBsAg) (6.7%), and immune tolerant phase of hepatitis B infection (3.0%). Among the 21,228 patients who were on treatment, 88.0%, 10.0% and 2.0% received nucleos(t)ide analogues (NAs), interferon or combination of NAs and interferon, respectively. The proportion of patients who received preferred NAs (entecavir or tenofovir disoproxil fumarate) had increased from 13.5% in 2003 to 79.7% in 2016.

Conclusions: We concluded that middle-aged men accounted for most of the patients with chronic hepatitis B in this cross-sectional study. About half of the patients were HBeAg-positive. NAs were the most commonly used therapy, and use of the preferred NAs had steadily increased in the past decade.

Keywords

Hepatitis B, Treatment, Registry

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 322-328  [ Html ] [ PDF Full-text ]

© The Authors 2019. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non-commercial and is otherwise in compliance with the license.

 

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