Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 11 / 16 / 2019

Articles

HBV cccDNA and Its Potential as a Therapeutic Target

REVIEW ARTICLE

HBV cccDNA and Its Potential as a Therapeutic Target

Anjing Zhu, Xinzhong Liao, Shuang Li, Hang Zhao, Limin Chen, Min Xu* and Xiaoqiong Duan*

Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China
*Correspondence to: Min Xu and Xiaoqiong Duan, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu 610052, China. Tel: +86-135-4080-7307, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. (MX) or This email address is being protected from spambots. You need JavaScript enabled to view it. (XD)

Journal of Clinical and Translational Hepatology 2019;7(3):258-262 DOI: 10.14218/JCTH.2018.00054
Received: September 26, 2018 Accepted: July 10, 2019 Published online: July 31, 2019

Abstract

Chronic hepatitis B virus infection continues to be a major health burden worldwide. It can cause various degrees of liver damage and is strongly associated with the development of liver cirrhosis and hepatocellular carcinoma. Covalently closed circular DNA in the nucleus of infected cells cannot be disabled by present therapies which may lead to HBV persistence and relapse. In this review, we summarized the current knowledge on hepatitis B virus covalently closed circular DNA and its potential role as a therapeutic target.

Keywords

Hepatitis B virus (HBV), Covalently closed circular DNA (cccDNA), Therapeutic target

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 258-262  [ Html ] [ PDF Full-text ]

© The Authors 2019. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

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