Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Tuesday, 09 / 17 / 2019

Articles

HCV Extrahepatic Manifestations

REVIEW ARTICLE

HCV Extrahepatic Manifestations

Lucija Kuna1, Jelena Jakab2,3, Robert Smolic2,4, George Y Wu5 and Martina Smolic*,1,4

1Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Osijek, Croatia
2Department of Pathophysiology and Physiology with Immunology, Faculty of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Osijek, Croatia
3Department of Internal Medicine, Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia
4Department of Pharmacology, Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia
5Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA
*Correspondence to: Martina Smolic, Department of Pharmacology, J. J. Strossmayer University of Osijek Faculty of Medicine Osijek, J. Huttlera 4, Osijek 31000, Croatia. Tel: + 385-31-512-800, Fax: +385-31-512-833, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(2):172-182 DOI: 10.14218/JCTH.2018.00049
Received: September 2, 2018 Accepted: March 17, 2019 Published online: April 21, 2019

Abstract

Hepatitis C virus (HCV) has been shown to affect many tissues other than liver. However, of the many extrahepatic manifestations (EMs) that have been associated with HCV, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes and neurological disorders, only a few have been shown to be directly related to HCV infection of extrahepatic tissues. HCV-triggered immune-mediated mechanisms account for most of the EMs. It is estimated that up to 74% of patients with chronic hepatitis C can develop at least one EM. All HCV patients with EMs should be considered for antiviral therapy, although not all will resolve with sustained virological response.

Keywords

Hepatitis C virus, Hepatic stellate cells, B cell lymphomas, pancreatic B cell, TGF-β-dependent signaling pathway, Extrahepatic manifestations, Direct-acting antivirals

 

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 172-182  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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