Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Tuesday, 09 / 17 / 2019

Articles

Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population

ORIGINAL ARTICLE

Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population

Yuan Li1, Shousheng Liu3,4, Yuqiang Gao1, Huan Ma1, Shuhui Zhan1, Yan Yang1, Yongning Xin*,1,2,4 and Shiying Xuan*,1,4

1Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China
2Department of Infectious Disease, Qingdao Municipal Hospital, Qingdao, China
3Central Laboratories, Qingdao Municipal Hospital, Qingdao, China
4Digestive Disease Key Laboratory of Qingdao, Qingdao, China
*Correspondence to: Shiying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao 266011, Shandong, China. Tel: +86-532-88905508, Fax: +86-532-88905293, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; Yongning Xin, Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao, Shandong 266011, China. Tel: +86-532-82789463, Fax: +86-532-85968434, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(2):99-105 DOI: 10.14218/JCTH.2019.00010
Received: February 13, 2019 Accepted: April 12, 2019 Published online: May 4, 2019

Abstract

Background and Aims: Colorectal cancer is associated with non-alcoholic fatty liver disease (NAFLD) and other metabolic syndromes, such as obesity, abnormal blood glucose, and dyslipidemia. The relationship of NAFLD and colorectal adenoma, which is the precursor of colorectal cancer, is worthy of discussion. The aim of this study was to investigate the association between colorectal adenoma and NAFLD, colorectal adenoma and metabolic syndrome in a Chinese Han population.

Methods: This retrospective study analyzed the relationship between NAFLD and colorectal adenoma in 1089 patients in Qingdao municipal hospital. Subjects were divided into a colorectal adenoma group (n = 267) and a control group (n = 822). NAFLD and the controlled attenuation parameter (CAP) value were determined by abdominal ultrasound and FibroScan.

Results: Patients with NAFLD in the colorectal adenoma group and the control group represented 142 cases (53.2%) and 360 cases (43.8%), respectively. The mean CAP value in the colorectal adenoma group was significantly higher than that in the control group. The values of body mass index, triglyceride, high-density lipoprotein cholesterol, aspartate aminotransferase, fasting plasma glucose, and uric acid were also significantly higher in the colorectal adenoma group than in the control group. Multifactor logistic regression analysis showed that the sex, NAFLD, CAP, body mass index, triglyceride, aspartate aminotransferase, and fasting plasma glucose were significant risk factors for colorectal adenoma. Besides, NAFLD and CAP value were significant risk factors for colorectal adenoma in males but not in females.

Conclusions: NAFLD and metabolic syndrome were tightly associated with the risk of colorectal adenoma in this Chinese Han population. The effect of NAFLD on colorectal adenoma was prominent in males rather than in females.

Keywords

Non-alcoholic fatty liver disease (NAFLD), Colorectal adenoma, Metabolic syndrome, Controlled attenuation parameter (CAP)

 

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 99-105  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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