Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Tuesday, 09 / 17 / 2019

Articles

Fatty Liver Disease and Gut Microbiota: A Comprehensive Update

REVIEW ARTICLE

Fatty Liver Disease and Gut Microbiota: A Comprehensive Update

Lyna Campo, Sara Eiseler, Tehilla Apfel and Nikolaos Pyrsopoulos*,

Division of Gastroenterology and Hepatology, University Hospital, Rutgers New Jersey Medical School, Newark, NJ, USA
*Correspondence to: Nikolaos Pyrsopoulos, Gastroenterology and Hepatology, University Hospital, Rutgers New Jersey Med. Sch. 185 S Orange Ave, Newark, NJ 07103, USA. Tel: +1-973-972-5252, Fax: +1-973-972-3144, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(1):56-60 DOI: 10.14218/JCTH.2018.00008
Received: February 17, 2018 Accepted: October 3, 2018 Published online: December 28, 2018

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the accumulation of fat in the liver in the absence of secondary causes. NAFLD is a multifactorial disease that results from the interaction of genetic predisposition and metabolic, inflammatory and environmental factors. Among these factors, dysregulation of gut microbiome has been linked to the development of fatty liver disease. The microbiome composition can be modified by dietary habits leading to gut microbiome dysbiosis, especially when a diet is rich in saturated fats, animal products and fructose sugars. Different species of bacteria in the gut metabolize nutrients differently, triggering different pathways that contribute to the accumulation of fat within the liver and triggering inflammatory cascades that promote liver damage. In this review, we summarize the current understanding of the roles of gut microbiota in mediating NAFLD development and discuss possible gut microbiota-targeted therapies for NAFLD. We summarize experimental and clinical evidence, and draw conclusions on the therapeutic potential of manipulating gut microbiota to decrease the incidence and prevalence of fatty liver disease.

Keywords

Nonalcoholic fatty liver disease, Gut microbiome, Dysbiosis, Endotoxins, Choline metabolism

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 56-60  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

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