Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Thursday, 12 / 12 / 2019

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Practical Use of Transient Elastography in Screening for Nonalcoholic Steatohepatitis in a Japanese Population

ORIGINAL ARTICLE

Practical Use of Transient Elastography in Screening for Nonalcoholic Steatohepatitis in a Japanese Population

Haruka Hirono, Kazuhiko Watanabe, Katsuhiko Hasegawa and Shogo Ohkoshi*

Department of Internal Medicine, The Nippon Dental University School of Life Dentistry at Niigata, Chuo-ku, Niigata, Japan
*Correspondence to: Shogo Ohkoshi, Department of Internal Medicine, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan. Tel: +81-25-211-8243, Fax: +81-25-267-1582, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(2):127-131 DOI: 10.14218/JCTH.2018.00048
Received: August 22, 2018 Accepted: May 28, 2019 Published online: June 25, 2019

Abstract

Background and Aims: Fatty infiltration of liver may induce insulin resistance (IR), and a proportion of patients with nonalcoholic fatty liver disease (NAFLD) is diagnosed with nonalcoholic steatohepatitis. Transient elastography is gaining popularity as a means of non-invasively determining both liver stiffness (fibrosis level) and degree of fatty infiltration, expressed as controlled attenuation parameter (CAP) value.

Methods: The aims of this study were to investigate the association between IR and level of fatty liver, and to identify the group at a greater risk of nonalcoholic steatohepatitis using transient elastography and other noninvasive fibrosis markers. A total of 169 patients without chronic hepatitis B and C were analyzed.

Results: The CAP value was significantly associated with IR (HOMA-IR ≥2.5; AUROC = 0.81), and the optimal cut-off to discriminate IR was 264 dB/m. The liver stiffness measurement and aspartate aminotransferase-to-platelet ratio index values were significantly higher for CAP ≥264 than in CAP <264. The 9 patients among the overall 169 patients (5.3%) and among the 102 NAFLD patients (8.8%) who showed ≥264 dB and ≥7.0 kPa in transient elastography could represent good candidates for liver biopsy.

Conclusions: Evaluation of NAFLD based on CAP values was useful in diagnosing IR. About 9% of NAFLD patients in a Japanese outpatient clinic with a few metabolic complications might be considered good candidates for liver biopsy to confirm nonalcoholic steatohepatitis.

Keywords

NAFLD, Insulin resistance, NASH, Transient elastography, CAP, Fibrosis marker

 

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 127-131  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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